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Interfaces of Chemistry, Life Sciences & Physics Lecture Series: Prof. Mitch Winnik, UofT
Start Date: 1/16/2015Start Time: 3:30 PM
End Date: 1/16/2015End Time: 4:30 PM
Event Description:

Metal-chelating polymers designed for biomedical applications

Professor Mitchell A. Winnik

Department of Chemistry, University of Toronto

More than a decade ago, Torchillin1 introduced the idea of using metal chelating polymers (MCPs) for biomedical applications. He had in mind using these polymers as chelating agents for Gd3+ to enhance their use in magnetic resonance imaging, and as carriers for radioisotopes for radiotherapy applications. Over the past 8 years, we have been developing functional MCPs for covalent attachment to antibodies (Abs) with two different applications in mind.

The first set of applications involve assays based upon inductively coupled plasma mass spectrometry [ICP-MS], a technique widely used in mining and metallurgy for its ability to measure quantitatively, with high sensitivity, the presence of different metals in a sample. In analogy with fluorescence based bioassays, where one uses quantum dots or fluorescent dyes as labels, we use lanthanide (Ln) metal ions as labels. We design and synthesize MCPs as reagents for highly multiplexed immunoassays designed for detection by mass cytometry, a new technique developed by DVS Sciences in Toronto. In this technique, cells are injected individually into the plasma torch of a time-of-flight ICP-MS device at a rate of 1000 cells/s. The plasma vaporizes, atomizes, and ionizes the cell or bead and its contents, and is able to take (and analyze) ca. 30 mass spectra of the ion cloud generated from each cell. In this talk, I will describe the synthesis of various MCPs and their applications in multiplexed immunoassays.2 

We also collaborate with Professor R. M. Reilly in our Faculty of Pharmacy on the application of these immunoconjugates as carriers for 111In for radioimmunotherapy and SPECT imaging related to the treatment of HER2 positive breast cancers. 111In undergoes Auger decay, emitting electrons that are highly destructive to cells but travel only short distances (up to 1 mm). For effective use in therapy, we need to develop polymer conjugates that not only target tumor cells, but are transported to the cell nucleus, to ensure localized destruction of nuclear DNA.

  • Torchilin, V. P.; Klibanov, A. L.Crit. Rev. Ther. Drug. 1991, 7, 275; Torchilin, V. P. Bioconjugate Chem. 1999, 10, 146.
  • Majonis, D.; Herrera, I.; Ornatsky, O.; Shulze, M.; Lou, X.; Soleimani, M.; Nitz, M.; Winnik, M. A.; Anal. Chem., 2010, 82, 8961; N. Illy, D.
  • Majonis, I. Herrera, O. Ornatsky, M. A. Winnik. Biomacromolecules, 2012, 13, 2359–2369.
This lecture is supported by the Betts Lecture Fund.

All are welcome to attend.

Click here to download the event poster in PDF.
Location Information:
University of Manitoba - Fort Garry - Buller Building  (View Map)
45 Chancellors Circle
Winnipeg, MB
Room: 207
Contact Information:
Name: Mazdak Khajehpour, Assistant Professor of Chemistry
Professor Mitch Winnik, U of T
Attachments For This Event:
    > Event Poster in PDF
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  • Additional Information:
    Seminar Series is supported by the Department of Chemistry, Physics and Astronomy, Biological Sciences Computer Science, Microbiology and Biosystems, and the Faculty of Engineering.

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